It’s safe to say that Charlotte’s Web is probably the most recognized CBD brand out there — and it’s not all hype. This company pioneered the CBD industry and made it their mission to de-stigmatize CBD by setting the bar high for transparency. They produce and oversee their organic CBD products from seed to sale, standing behind them with a solid return policy. 
The studies on CBD for headache pain are still in their infancy, but with promising results so far. A 2017 study published in the Cannabis and Cannabinoid Research Journal worked with 26 people who were experiencing rebound headaches. The pain management results were better for the cannabis-nabilone formula over either ibuprofen or nabilone alone. (As a nerdy side note, the article is a great read if you’re interested in the history of cannabis as a pain reliever.)
Research on CBD and anxiety has generally looked at cannabis as a whole product, not as CBD as a standalone compound. Some studies suggest that it can help with anxiety: like this 2011 study that suggests CBDcan reduce social anxiety or this 2015 review that says CBD could be promising for many forms of anxiety. It’s also important to consider whether the CBD comes from the cannabis plant and therefore may include THC, a cannabinoid that for some, induces anxiety. Read our comprehensive article on CBD and anxiety, here.
Consume CBD oil via edibles to enjoy a sweet treat. There are many edible products available for purchase that contain CBD oil as an ingredient. These are often in the form of gummies or other candies, but also come as an edible liquid that you can mix into foods, such as smoothies. If you live in a state where it’s legal, go online and choose whichever edibles sound good to you. After purchasing, make sure to read the instructions and take them as directed.[2]
Pharmacology published a study in 2016 looking at medical marijuana for migraines, specifically in relation to its effects on serotonin, with very positive results. You’ll notice that neither study looked at CBD in isolation from other cannabinoids (which is an issue with a lot of research on CBD and pain). Truthfully, the research on CBD alone just isn’t sufficient to make any pronouncements about its effects on headache pain.
Transparency: Fab’s website features third-party lab results for most products. They only have a lab test for one of their tinctures though (which shows results for cannabinoid potency, as well as contaminants like pesticides). Customer service pointed out that the same CBD oil is used for all their products, but since potencies do vary, we appreciate companies that show potency testing for all products.
At first, I was wary. Although I live in Los Angeles, where it seems like there’s a medical marijuana depot on every corner, I’m not one for doing drugs (legal or otherwise). I mean, I don’t even take Advil when I get a headache!  But despite the fact that CBD oil is made from hemp, it doesn’t contain THC. THC is the compound responsible for the “high” that comes with ingesting marijuana. In fact, scientific reviews have proven that CBD “does not interfere with several psychomotor and psychological functions,” and is safe to ingest without any side effects. Let me repeat: YOU WILL NOT GET HIGH FROM CBD!
Schizophrenia is a disorder that generally requires heavy antipsychotic drugs just to manage daily life. However, this systematic review notes that such drugs “provide limited cognitive benefits,” which is extremely rough given the side effects antipsychotic drugs can have. As discussed in the review, CBD may be a possible alternative to such heavy prescription drugs.
CBD is the major non-euphorigenic component of Cannabis sativa. Some research is beginning to show that CBD is different than other well-studied cannabinoids. All cannabinoids function as ligands, meaning they dock onto the binding site of a protein and have the ability to modulate a receptor’s behavior. CB1 receptors are widely distributed, but are particularly abundant in areas of the brain, including those concerned with movement, coordination, sensory perception, emotion, memory, cognition, autonomic and endocrine functions.
Vaporizers – Many state-licensed cannabis dispensaries offer high CBD strains of cannabis flower. This allows for reduced risk of paranoia while allowing for a high medicinal dose of CBD. Vaporizers are used to heat up the flower and remove the properties or compounds of the plant that you are looking for without combustion or smoking. Vaporizers use convection much like a convection oven.
In addition to all the benefits we’ve already discussed, CBD has been proven to have antioxidant and neuroprotective effects. This means that it helps repair the damage from oxidative stress, which is believed to be a primary cause of diseases like Alzheimer’s, Parkinson’s, ALS — even heart disorders and some forms of cancer. This is a hugely beneficial effect of CBD.

 This study investigated how CBD could affect subjects with liver injuries resulting from chronic and binge alcohol consumption. CBD was given to subjects (in this case, mice and human blood samples) that had been fed alcohol. In short, the analysis demonstrated that CBD lessened the elevated liver enzymes and the increased liver triglyceride. It also reduced fat droplet accumulation.


Elixinol has a wide range of products, but their CBD Tincture does the trick. It’s the cream of the crop regarding CBD oils and that reflects in its price. One dropper (1mg) from the 300 series contains 10mg of CBD. This allows you to get precise amounts of CBD and no guess work is required. Elixinol has received numerous awards for their products and extraction process.
Our hemp oil tinctures offer the most accessible means to getting started with CBD hemp oil supplements. Registering our lowest price point among our products, our 1 oz tinctures contain the lowest concentration of CBD in our products. With around 1 mg of CBD per serving, our 1 oz tinctures are good for those looking to integrate the smallest amount of CBD into their daily routine. The tinctures in the 2 oz bottle add 2.5 times the potency, for a total of 500 mg per 2 oz bottle.
Cannabidiol, more commonly known as CBD, is one of 113 known cannabinoids found in cannabis. But unlike its better-known counterpart THC (tetrahydrocannabinol), responsible for cannabis’ mind-altering effects, extensive research suggests that CBD is not psychoactive, and with none of the often-damaging side effects accompanying synthetic pharmaceuticals.
Take CBD oil to help treat your bowel disease. Some scientists claim that CBD and THC interact in a productive way with the bodily system that controls gut function. Because of this, people with bowel diseases, such as Crohn’s Disease, sometimes benefit from using CBD oil. If you have a bowel disease, consider taking CBD oil. It may also alleviate some of your pain.[12]
With so many companies popping up every day, we’ve done the hard work for you. We bring you the best CBD oil guide and the top 25 brands that made our list based on CBD oil quality, effectiveness, customer service and of course price. Please note, this article is updated constantly, so don’t forget come back from time to time to see the most updated information.
And lastly, don’t hesitate to speak with a marijuana doctor or health professional about using CBD oil. And please note,  it is not our goal for any of the information on here to come across as clinical advice or medical recommendations. If you live in a state with legalized medical marijuana, make sure you take full advantage of the resources that are available to you – getting a licensed MMJ card is easier than it has ever been before, and it could very well be one of the best decisions you’ve ever made for yourself.
Research on CBD and anxiety has generally looked at cannabis as a whole product, not as CBD as a standalone compound. Some studies suggest that it can help with anxiety: like this 2011 study that suggests CBDcan reduce social anxiety or this 2015 review that says CBD could be promising for many forms of anxiety. It’s also important to consider whether the CBD comes from the cannabis plant and therefore may include THC, a cannabinoid that for some, induces anxiety. Read our comprehensive article on CBD and anxiety, here.
People who experience psychosis may produce too much or even too little cannabinoids (from overactive dopamine receptors). CBD is milder than our internal cannabinoids and helps to re-establish a balance of cannabinoids in the brain. CBD also helps lower inflammation, which is often increased in schizophrenia. THC, on the other hand, is stronger than our internal cannabinoids (anandamide and 2-AG), this way potentially triggering psychosis [46, 48].
After months of visiting doctors and sitting through tests like a human lab rat, it was determined that there was a slight anomaly in the anatomy of my temporal lobe—the part of the brain that controls hearing, speech, and auditory comprehension—which explains why every time I have a seizure, I suddenly don’t understand the English language. Epilepsy can’t be cured, so the only course of action available for me was to take a medication every day for the rest of my life. My neurologist prescribed a few different anti-convulsant medications, but they all made me feel tired, depressed, slow, and unlike myself—until finally, I found one that was slightly better than the rest.
While it is still classed illegal on a Federal level, individual U.S. states have adopted a more lenient policy towards this plant and some states now allow it for recreational use. The easing up of state laws has also allowed researchers to explore this miraculous plant and only recently has it been found to be an effective treatment for a variety of medical problems due to its CBD oil benefits. From cancer, anorexia, pain and inflammation management it seems like medical marijuana is placing a strong footing within the medical industry.
Tinctures – Typically tinctures are small glass or plastic “dropper” bottles that have cannabidiol oil mixed with a preserving solution such as alcohol. Tinctures were very a very common way to ingest botanical oils prior to the industrial revolution and are experiencing a resurgence in popularity as more people are looking for natural remedies. Tinctures with droppers allow you to put a few drops in your tea, under your tongue, or to bake the oil directly into your food. 

CBD derived from marijuana is a different story, and the law varies from state to state. But as long as you’re using CBD oil that contains less than 0.3 percent THC, you have nothing to be concerned about anywhere in the United States. On the other hand, if you want to take your CBD on a trip outside the country, definitely look into local laws to avoid getting into awkward situations while you’re away.
Honestly, I began to wonder if I was just experiencing the placebo effect. But on the one day, I didn’t take my CBD oil, I ended up picking a fight with my boyfriend (totally my fault) and let a few off-color remarks by a family member mess with my mood. Truly, I feel like it was a bit less anxious, both of those incidents could have been diverted.
CBD is a chemical found in marijuana. CBD doesn't contain tetrahydrocannabinol (THC), the psychoactive ingredient found in marijuana that produces a high. The usual CBD formulation is oil, but CBD is also sold as an extract, a vaporized liquid and an oil-based capsule. Food, drinks and beauty products are among the many CBD-infused products available online.
Pharmacology published a study in 2016 looking at medical marijuana for migraines, specifically in relation to its effects on serotonin, with very positive results. You’ll notice that neither study looked at CBD in isolation from other cannabinoids (which is an issue with a lot of research on CBD and pain). Truthfully, the research on CBD alone just isn’t sufficient to make any pronouncements about its effects on headache pain.
The furry subjects, 277 Wistar rats, were given a dose of CBD immediately after receiving a small electric shock. The CBD-treated subjects were found to spend less time frozen in fear when reintroduced to the context of the fearful event. This means the CBD disrupted consolidation (or more simply put: memory strengthening) of their specific and long-term fear memory.
Transparency: Fab’s website features third-party lab results for most products. They only have a lab test for one of their tinctures though (which shows results for cannabinoid potency, as well as contaminants like pesticides). Customer service pointed out that the same CBD oil is used for all their products, but since potencies do vary, we appreciate companies that show potency testing for all products.
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Although it is great that you have compiled a long list of the best CBD oils, so that we get some choice also as consumers, however, I rely believe in your well researched information that you share always, and so I feel the number 1. you shared, Purekana is going to make the choice for me. Ordering it tonight, and let’s see how my CBD journey goes from here. A bit nervous though!
However, switching to CBD oil from a conventional medication is far from a random stab in the dark. In fact, there was a large scale (and very well-documented) survey carried out less than two years ago that looked at precisely what percentage of patients were able to “swap” their side effect-inducing meds for a 100% natural, cannabis-based therapy.
In addition to all the benefits we’ve already discussed, CBD has been proven to have antioxidant and neuroprotective effects. This means that it helps repair the damage from oxidative stress, which is believed to be a primary cause of diseases like Alzheimer’s, Parkinson’s, ALS — even heart disorders and some forms of cancer. This is a hugely beneficial effect of CBD.
Moreover, scientists at the Cajal Institute showed promising results in regards to CBD and Multiple Sclerosis. They used animal models and cell cultures to find that CBD reversed inflammatory responses; within only ten days, mice that were used in the study had superior motor skills and showed progression in their condition. To date, there have been well over 20,000 published scientific articles on cannabinoids and their related effects on all sorts of medical ailments.
And lastly, don’t hesitate to speak with a marijuana doctor or health professional about using CBD oil. And please note,  it is not our goal for any of the information on here to come across as clinical advice or medical recommendations. If you live in a state with legalized medical marijuana, make sure you take full advantage of the resources that are available to you – getting a licensed MMJ card is easier than it has ever been before, and it could very well be one of the best decisions you’ve ever made for yourself.
Having a medical condition is difficult enough, but if that condition doesn’t respond to medical treatment, life can become a constant battle. Refractory epilepsy is also known as uncontrolled or drug-resistant epilepsy. This means that a person who is suffering from refractory epilepsies is not responding to traditional medicine and thus is unable to effectively manage his or her neurological disorder.
Moreover, a patient survey conducted by Project CBD, declared that “…cannabis appears to be an effective pain management tool with few negative side effects.” The study went on to say that a “…significant decrease in opiate usage among elderly patients while taking medical cannabis [was observed during trial].” In short, it has been portrayed clearly numerous times through valid and well-publicized clinical studies that cannabis is a practical option in terms of efficient pain management.
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