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A natural plant extract, CBD (or cannabidiol) has made a huge stir in the health scene over the last decade. It’s not hard to find plentiful anecdotal evidence of its benefits — people are using CBD for pain relief, mood regulation, cancer prevention, even seizure reduction. But if you’re in pain, you’re probably looking for more than anecdotal evidence. We get it — and we’re here to help.
Consume CBD oil if you want to quit smoking cigarettes. While consuming CBD oil, people sometimes report craving nicotine less. Withdrawal symptoms like anxiety and mood swings also aren’t as severe for many people when they take CBD oil. If you’re struggling to quit smoking cigarettes, try using CBD oil to potentially diminish your cravings and withdrawal symptoms.[13]

While it is still classed illegal on a Federal level, individual U.S. states have adopted a more lenient policy towards this plant and some states now allow it for recreational use. The easing up of state laws has also allowed researchers to explore this miraculous plant and only recently has it been found to be an effective treatment for a variety of medical problems due to its CBD oil benefits. From cancer, anorexia, pain and inflammation management it seems like medical marijuana is placing a strong footing within the medical industry.

But scientists have found that CBD doesn’t bind well with endocannabinoid receptors. Instead, CBD influences the system indirectly. This creates many benefits, which is why you’ll hear of CBD as a treatment for so many different medical conditions. And, unlike THC, it won’t make you high. When it comes to pain, we know that CBD has multiple functions. First, it influences neurotransmitters and receptors. One receptor known to be involved with pain and inflammation is called TRPV1 — also known as a vanilloid receptor. CBD binds to the TRPV1 receptor, influencing the way you perceive pain. CBD can also affect the production of neurotransmitters like serotonin and glutamate, which are related to pain sensation.


Deciding to use CBD oil as a natural therapy is one thing – figuring out which brand to use, what strength/concentration to use, and how much CBD to actually take is another thing altogether. Plus, with all of the products out there to choose from and their confusing mL/mg labels, it can be a nightmare trying to determine which one is best for you, or which one you should be taking for your specific condition.
I stopped by Moon Juice after work, feeling a little nervous and excited all at once. “You might notice that your body feels a bit heavy after you try it—sometimes when I take it I feel like I just want to sit down and chill,” said the women behind the Moon Juice counter who helped me. Prepped for potential side effects, I emptied one dropper’s worth of CBD oil into my chamomile tea as soon as I got home … And didn’t feel anything. A few hours later I got into bed and immediately fell asleep.
This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.
There’s still a lot of unknown territory, but early evidence for CBD’s efficacy is more than enough to justify further large-scale clinical studies — some of which are already in the works. These studies also point to the variety of effective ways to take CBD. This is an important point to keep in mind if you find yourself shopping for CBD products and wondering if the best CBD for pain is a topical, a tincture, or a vape product.
All of the product reviews listed on this website are real reviews from real users. Recommended brands are selected solely based on merit. Our vetting process includes analysis of product quality based on third party lab reports, customer service quality and responsiveness, industry reputation, company longevity and customer feedback. Per FTC guidelines, we do participate in the affiliate programs of some but not all of the recommended brands whereby we receive a small commission on purchases made through links on this website. Any references to third party products, prices or websites referenced in this group are subject to change without notice.

CBD is well tolerated in humans with doses up to 600 mg not resulting in psychotic symptoms (15). In the few small placebo-controlled studies performed, no significant CNS effects were noted. Oral CBD undergoes extensive first-pass metabolism via CYP3A4, with a bioavailability of 6%. Following single doses in humans, the half-life of CBD when taken orally is about 1 to 2 days.1 In vitro studies have shown that CBD is a potent inhibitor of multiple CYP isozymes, including CYP 2C and CYP3A (16, 17). Whether these in vitro observations are relevant at plasma concentrations likely to be seen in patients is unclear. In addition, given its metabolism via CYP3A4, clinical trials of CBD in patients receiving enzyme-inducing AEDs, such as carbamazepine or phenytoin, will require detailed pharmacokinetic studies.
Another field in which CBD is creating a buzz is in the area of mood disorders like anxiety and depression. Both conditions have been treated with a variety of medications, courtesy of Big Pharma, that have had varying levels of success. Again, the long list of side effects can be off-putting to someone who just wants to get through the day without the sweaty tension of anxiety or the gray haze of depression.
Moreover, scientists at the Cajal Institute showed promising results in regards to CBD and Multiple Sclerosis. They used animal models and cell cultures to find that CBD reversed inflammatory responses; within only ten days, mice that were used in the study had superior motor skills and showed progression in their condition. To date, there have been well over 20,000 published scientific articles on cannabinoids and their related effects on all sorts of medical ailments.
Take CBD oil to help treat your bowel disease. Some scientists claim that CBD and THC interact in a productive way with the bodily system that controls gut function. Because of this, people with bowel diseases, such as Crohn’s Disease, sometimes benefit from using CBD oil. If you have a bowel disease, consider taking CBD oil. It may also alleviate some of your pain.[12]
John Staughton is a traveling writer, editor, and publisher who earned his English and Integrative Biology degrees from the University of Illinois in Champaign, Urbana (USA). He is the co-founder of a literary journal, Sheriff Nottingham, and calls the most beautiful places in the world his office. On a perpetual journey towards the idea of home, he uses words to educate, inspire, uplift and evolve.

The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product.
It makes no sense to me that something that helps with anxiety has an irritability side effect – as a lot of my anxiety is co-mingled naturally with irritability. Further, I have noticed none of these side effects, given that if you become fatigued or sleepy, you adjust dose the next day. So I don’t call that a side effect – rather – an effect of taking too much.
At first, I was wary. Although I live in Los Angeles, where it seems like there’s a medical marijuana depot on every corner, I’m not one for doing drugs (legal or otherwise). I mean, I don’t even take Advil when I get a headache!  But despite the fact that CBD oil is made from hemp, it doesn’t contain THC. THC is the compound responsible for the “high” that comes with ingesting marijuana. In fact, scientific reviews have proven that CBD “does not interfere with several psychomotor and psychological functions,” and is safe to ingest without any side effects. Let me repeat: YOU WILL NOT GET HIGH FROM CBD!

It makes no sense to me that something that helps with anxiety has an irritability side effect – as a lot of my anxiety is co-mingled naturally with irritability. Further, I have noticed none of these side effects, given that if you become fatigued or sleepy, you adjust dose the next day. So I don’t call that a side effect – rather – an effect of taking too much.
Where do you buy CBD oils? You may have noticed that CBD products are everywhere these days. You can easily find CBD oil and other products online and in certain health food/vitamin stores or spas. To separate the highest quality products from the rest, look for one that has a certificate of analysis, or COA. This means that the manufacturer tests the product for contaminants, and it meets lab standards.
However, even if you do suffer from one of the above-mentioned chronic conditions, it’s still recommended you start out with the low potency oil first, at least until you gauge how your body reacts to the CBD. It’s important to understand that because everybody’s biochemistry is different, not everyone will react the same or get the same therapeutic effects from CBD oil.
Featuring the same benefits as our pure RSHO™ hemp oil in a reduced potency, another of our midrange products, RSHO™ liquid, contains 31 mg of CBD per serving. Available in Green, Blue, and Gold Label oils, RSHO™ liquid combines our flagship RSHO™ with medium chain triglyceride (MCT) oil derived from wholesome coconut oil and sustainably sourced palm oil. Unlike RSHO™ pure hemp oils, RSHO™ liquid doesn’t need to be refrigerated, making it convenient to store wherever you need it most.
Also listed among our low potency products is our bestselling CanChew® gum. With just 10 mg of CBD per piece of gum, it is easy to get started with CBD as a supplement, and adding more CBD to your diet is as simple as chewing another piece of gum. Another approachable product for those just starting out with CBD, CanChew® gum is a simple delivery method for getting your daily CBD.

Tinctures – Typically tinctures are small glass or plastic “dropper” bottles that have cannabidiol oil mixed with a preserving solution such as alcohol. Tinctures were very a very common way to ingest botanical oils prior to the industrial revolution and are experiencing a resurgence in popularity as more people are looking for natural remedies. Tinctures with droppers allow you to put a few drops in your tea, under your tongue, or to bake the oil directly into your food.
Take CBD oil to help treat your bowel disease. Some scientists claim that CBD and THC interact in a productive way with the bodily system that controls gut function. Because of this, people with bowel diseases, such as Crohn’s Disease, sometimes benefit from using CBD oil. If you have a bowel disease, consider taking CBD oil. It may also alleviate some of your pain.[12]

CBD may be best known for its relaxing, calming effects. CBD reduces autonomic arousal, having the inverse effect of THC on the body. CBD’s anti-anxiety effect is why many in the cannabis community talk about how CBD relieves paranoia, although that is not scientifically proven yet. CBD is also known for its anti-nausea and pain relieving effects. It really depends on why your body’s specific needs and the quantity in which you take CBD.

In short, the results of the survey (which were published in the Journal of Pain Research) showed that roughly 42% and 46% (respectively) of participants claimed they were able to use cannabis in place of traditional medical to effectively treat their specific medical ailment. So if you’re wondering how to know if you need CBD for pain, remember that you’re certainly not alone.
CBD derived from marijuana is a different story, and the law varies from state to state. But as long as you’re using CBD oil that contains less than 0.3 percent THC, you have nothing to be concerned about anywhere in the United States. On the other hand, if you want to take your CBD on a trip outside the country, definitely look into local laws to avoid getting into awkward situations while you’re away.
I use this for my anxiety and for my arthritis. The topical works great for my chronic neck pain. The best way to go is to get your own raw, tested material and use it in whatever form you like. It’s quite easy to make your own extract. This has worked better for me, rather than relying on a purchased, untested product – where some seem to work and others are a waste. But even with those that work, of course the cost is ridiculous and not affordable, thanks to all these corporate-pleasing laws in place, not there for the people – don’t delude yourselves.
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