However, switching to CBD oil from a conventional medication is far from a random stab in the dark. In fact, there was a large scale (and very well-documented) survey carried out less than two years ago that looked at precisely what percentage of patients were able to “swap” their side effect-inducing meds for a 100% natural, cannabis-based therapy.

There are likely very complex relationships also occurring between various Cannabinoids in Cannabis that may lead to certain medical efficacy. That is important to remember when considering the consumption of products that contain Cannabinoids. There is an attractiveness to isolating a specific chemical, researching it, patenting synthetic derivatives, and marketing specific drugs. That said, the relationships are complex, will likely take years to understand, and many patients I’ve met appear to find the most medical benefit from a diverse group of Cannabinoids whose interactions are not particularly well understand, but the results are hard to argue with.
Hemp oil does have a number of uses and is often marketed as a cooking oil or a product that is good for moisturizing the skin. It is also used in the production of certain soaps, shampoos, and foods. It is also a basic ingredient for bio-fuel and even a more sustainable form of plastic. Hemp has been cultivated and used for roughly 10,000 years, and it definitely has useful purposes. However, a lack of cannabinoids, namely CBD, means that it has little therapeutic value.
Other targets for CBD include transient receptor potential (TRP) channels that are involved with the modulation of intracellular calcium (1, 6). Cannabinoids are highly lipophilic, allowing access to intracellular sites of action, resulting in increases in calcium in a variety of cell types including hippocampal neurons. CBD actions on calcium homeostasis may provide a basis for CBD neuroprotective properties.
With so many companies popping up every day, we’ve done the hard work for you. We bring you the best CBD oil guide and the top 25 brands that made our list based on CBD oil quality, effectiveness, customer service and of course price. Please note, this article is updated constantly, so don’t forget come back from time to time to see the most updated information.
We’ve ranked every one of the high-strength CBD vape oils on this list according to a variety of attributes. We’ve graded them according to potency, quality, strength, flavor, shipping speed, customer service, and pricing; among other factors. Every one of the products on this list has been hand-selected by our editorial team. No matter which product you buy from this list, you can rest easy knowing that you’re buying one of the best high-concentration CBD oils on the planet today.
In fact, not only will CBD not make you high, it has been proven to counteract the psychoactivity of THC. This property makes CBD highly useful as a medical treatment for a wide range of conditions. In terms of the CBD products you can buy, the amount of THC present varies from none at all in a pure CBD Isolate to a minimal amount (less than 0.3%) in a Full-Spectrum CBD product.
The endocannabinoid system is spread throughout your brain and body, but primarily throughout your central nervous system. The interaction between cannabinoids and receptors is what produces effects like the regulation of mood, pain, appetite, inflammation, and memory. Plant-based cannabinoids, found in cannabis plants, also interact with the receptors (whimsically named CB1 and CB2) in the endocannabinoid system, and each affects your body in different ways. CBD and its infamous cousin THC are the 2 most well-known cannabinoids.
Based in Los Angeles, Calm by Wellness plans to be among the largest hemp-growing and CBD extraction facilities in the world by the end of 2019. The company sources their hemp from Colorado and uses clean CO2 technology to extract their CBD and other cannabinoids (no THC though!). The company is also GMP and ISO9001 food-grade manufacturer certified.
What you gain from Full Spectrum CBD is called the “entourage effect.” Studies have suggested that CBD is most effective when it’s combined with other cannabinoids. Each cannabinoid has its own properties and confers its own benefits. Working together, a synergy is created that boosts the healing properties of CBD. Full spectrum CBD does, however, bring with it the sticky issue of THC. The government regulates concentration levels of THC at 0.3 percent, an amount which results in minimal psychoactivity.

Vape Pens – Perhaps the easiest way to get the CBD Oil into your body is through a vape pen. A vape pen is about the size of an ink pen but has a CBD oil cartridge with a heating element. Many people like vape pens because there is very little in the way of odor after using it and it allows for a lot of discretion because it can be pulled out of your pocket and used on demand.
I have to agree with Tanya. The higher the mg in the bottle, the fewer drops you take to equal the smaller dose from a lower mg bottle. Right? I actually clicked this article hoping to find info about actual CBD content. I read a COA report for a brand out of CO that said it is .6% CBD. That seems way low. But I know nothing about this stuff yet. I used to just smoke regular ole weed back when a quarter ounce cost $25 and based my choice on smell and appearance… or availability…. I feel like I need to be a little more scientific now.
Another point worth clarifying is the difference between hemp seed oil (or hemp oil) and CBD oil. There’s confusion on this point for the very good reason that both CBD oil and hemp seed oil are extracted from the industrial hemp plant. But there’s a big difference between the 2. Hemp seed oil has been pressed from hemp seed, and it’s great for a lot of things — it’s good for you, tastes great, and can be used in soap, paint — even as biodiesel fuel.

It is thought that by applying the correct amount of cannabis, the cannabinoids can help with the promotion of lipids which help fight chronic skin conditions including acne and psoriasis. Some also claim that cannabis oil has the power to remove wrinkles and skin spots. While we wouldn’t bank on it being the “anti-aging” miracle, it is helping millions of people worldwide deal with a variety of skin diseases including eczema and rosacea.

But it also requires careful research before making a purchase. Because the cannabis plant readily absorbs pesticides, heavy metals and other chemicals that are in the soil and water, it’s so important that cannabis plants are frequently tested while they are growing. And it’s up to manufactures to test CBD products, too. When you are shopping for CBD oil, look for products that have been tested for contaminants and for CBD vs. THC levels.
Featuring the same benefits as our pure RSHO™ hemp oil in a reduced potency, another of our midrange products, RSHO™ liquid, contains 31 mg of CBD per serving. Available in Green, Blue, and Gold Label oils, RSHO™ liquid combines our flagship RSHO™ with medium chain triglyceride (MCT) oil derived from wholesome coconut oil and sustainably sourced palm oil. Unlike RSHO™ pure hemp oils, RSHO™ liquid doesn’t need to be refrigerated, making it convenient to store wherever you need it most.

However, if it was sourced from actual marijuana (i.e. cannabis that contains more than 2% THC by volume), then it is technically illegal. Most of the best CBD oils for pain that you find in dispensaries in states like Colorado, California, and Washington (as well as other states where weed is legal) will have been extracted from marijuana plants — not industrial hemp plants. Unfortunately, this means that these products are not allowed to be sold online and shipped across state lines to “non-legal” states.


Topicals – Topicals are typically salves or creams that have been infused with cannabis or hemp oil. This allows for easy use to treat problem areas. Many senior citizens use topicals for arthritis or other auto-immune disorders however because of restrictions imposed by various agencies we are not allowed to say whether this is an effective treatment or now. However, a quick Google search will help you find what you are looking for in terms of effectiveness.
This isn’t new but had to be mentioned. One of the major and well-known benefits of cannabis is its ability to treat pain and helping with pain management. It has the capabilities of assisting with chronic pain as well as inflammation. Furthermore, it has been found to help patients deal with severe rheumatism and arthritis as well as other chronic pains.
Research on CBD and anxiety has generally looked at cannabis as a whole product, not as CBD as a standalone compound. Some studies suggest that it can help with anxiety: like this 2011 study that suggests CBDcan reduce social anxiety or this 2015 review that says CBD could be promising for many forms of anxiety. It’s also important to consider whether the CBD comes from the cannabis plant and therefore may include THC, a cannabinoid that for some, induces anxiety. Read our comprehensive article on CBD and anxiety, here.
I have read about studies from Europe (not very specific I know) that suggest CBD might work better for some people if combined with some level of THC. Also, the getting high part can be helpful, although not for everybody, of course. A second point – I don’t hear very much about CBD eliminating or almost eliminating pain for people with severe pain. Helpful, but, so far at least, it doesn’t seem that CBDs can replace opioids or substantially reduce pain for all chronic pain patients. Maybe someday.

Thanks to research and modern technology the cannabis plant is now being processed in numerous ways to help patients from across the world. Patients are able to benefit of it’s cannabinoids CBD and THC in the form of oils. One of those ways is in the form of CBD Oil. To create CBD oil, solvents, such as CO2 are used to separate the cannabinoids (in the form of oils) from the plant material, creating the highly concentrated product.


CBD is well tolerated in humans with doses up to 600 mg not resulting in psychotic symptoms (15). In the few small placebo-controlled studies performed, no significant CNS effects were noted. Oral CBD undergoes extensive first-pass metabolism via CYP3A4, with a bioavailability of 6%. Following single doses in humans, the half-life of CBD when taken orally is about 1 to 2 days.1 In vitro studies have shown that CBD is a potent inhibitor of multiple CYP isozymes, including CYP 2C and CYP3A (16, 17). Whether these in vitro observations are relevant at plasma concentrations likely to be seen in patients is unclear. In addition, given its metabolism via CYP3A4, clinical trials of CBD in patients receiving enzyme-inducing AEDs, such as carbamazepine or phenytoin, will require detailed pharmacokinetic studies.
Consume CBD oil via edibles to enjoy a sweet treat. There are many edible products available for purchase that contain CBD oil as an ingredient. These are often in the form of gummies or other candies, but also come as an edible liquid that you can mix into foods, such as smoothies. If you live in a state where it’s legal, go online and choose whichever edibles sound good to you. After purchasing, make sure to read the instructions and take them as directed.[2]
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Cannabidiol pharmacological effects are mediated through G protein coupled receptors, cannabinoid type I (CB1) and cannabinoid type II (CB2), which are highly expressed in the hippocampus and other parts of the central nervous system (2). When activated, CB1 receptors inhibit synaptic transmission through action on voltage-gated calcium and potassium channels, which are known to modulate epileptiform and seizure activity (3). CB2 receptors are primarily expressed in the immune system and have limited expression in the central nervous system. The effects of CBD are CB2 receptor independent (3).

Featuring the same benefits as our pure RSHO™ hemp oil in a reduced potency, another of our midrange products, RSHO™ liquid, contains 31 mg of CBD per serving. Available in Green, Blue, and Gold Label oils, RSHO™ liquid combines our flagship RSHO™ with medium chain triglyceride (MCT) oil derived from wholesome coconut oil and sustainably sourced palm oil. Unlike RSHO™ pure hemp oils, RSHO™ liquid doesn’t need to be refrigerated, making it convenient to store wherever you need it most.

This article provides a wealth of practical information for the individual considering CBD as an adjunctive or alternative treatment for pain and or anxiety. CBD works in the body by manipulating receptors throughout organ tissues, the immune system, the pain response system, the hormonal system, and other systemic regulatory systems. While CBD oils have not been reviewed or approved by the FDA for the treatment of these conditions, a wealth of literature, both anecdotal and research-related now exists to help describe both their safety and effectiveness. As discussed in this article, the potential new adopter must be mindful of several important items. First, only those products that are sourced from Industrial Hemp will be considered legal in all states. One must be careful if the product you choose is sourced from the marijuana plant, as those products may contain THC levels above the legal limit in your given state. Secondly, all products are NOT created equal – they differ significantly in strength, absorption, and elimination by the body and in the manner in which they are formulated. One should be mindful of the differences in doses available for each of these products, starting at a low or moderate dose and increasing as needed in order to find the lowest dose that provides the desired relief. In this way, one can individualize usage to maximize effectiveness, while minimizing risk, a proper goal for the use of all medicinals.
Cannabis oil preparations have been used historically in medicine for millennia. Only recently, cannabis and chemically-related compounds have come back to being considered of beneficial value. A prominent compound found in cannabis, CBD, or cannabidiol, has been shown to have some benefits. What is CBD oil good for? Find out all about CBD, including the extensive CBD oil benefits list, CBD oil uses and the many different CBD oil forms.
Vape Pens – Perhaps the easiest way to get the CBD Oil into your body is through a vape pen. A vape pen is about the size of an ink pen but has a CBD oil cartridge with a heating element. Many people like vape pens because there is very little in the way of odor after using it and it allows for a lot of discretion because it can be pulled out of your pocket and used on demand.
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